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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence theThe siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamineCDK1 gene was successfully silenced by its siRNA, and the CDK1 protein expression level was decreasedThe DNA content analysis showed that transfection of CDK1 siRNA led to cells accumulating in G/M phaseThe decreased CDK1 expression by siRNA silencing gave rise to cell cycle arrest in G/M phase but did

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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Elastoplastic frictional contact problem study on interference fits of compressor

ZHANG Hongwu, WU Changhua, LIAO Aihua

Frontiers in Energy 2008, Volume 2, Issue 3,   Pages 313-319 doi: 10.1007/s11708-008-0026-1

Abstract: A locomotive-type turbocharger compressor with 24 blades under combined centrifugal and interference-fitdecrease the difficulty of the assembly process and ensure the safety of the working state, the amount of interference

Keywords： computation     thickness     interference-fit     interference     unspecified    

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Laser interference fabrication of large-area functional periodic structure surface

Lei WANG, Zi-Han WANG, Yan-Hao YU, Hong-Bo SUN

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 493-503 doi: 10.1007/s11465-018-0507-9

Abstract: The laser interference technique in particular has received attention because of its simplicity, lowHere, we reviewed the work on laser interference fabrication of large-area functional periodic structuresFor the common cases, four-beam interference and multi-exposure of two-beam interference were emphasizedThe relations between multi-beam interference and multi-exposure of two-beam interference were comparedPerspectives on future directions and applications for laser interference were presented.

Keywords： laser interference     four-beam interference     multi-exposure of two-beam interference     additive fabrication    

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: The transient transfection of survivin-targeted siRNA to Lovo cells and its influence on the biologicalTwo pairs of 19 base pairs (bp) siRNA-specific targeted survivin gene were designed and synthesized by

Keywords： control     therapy     influence     Survivin-1     colorectal carcinoma    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as longDendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecturebeen established, some of them out-performing the currently available nonviral vectors in delivering siRNAadvantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNAself-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: The aim of the present study was to construct the lentiviral RNA interference (RNAi) vector of rat OBRbgene and evaluate the effects of siRNA on silencing OBRb gene expression.The target sequence of siRNA-OBRb was designed, and the complementary DNA containing both sense and antisenseThe target sequence of siRNA-OBRb was successfully cloned to pRNA-lentivector-VGFP, and the RNAi protocol

Keywords： receptors     leptin     RNA interference     lentivirus vector    

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with multi-walled carbon nanotubes: preparation, characterization, and application for electromagnetic interference

Jian LI,Caichao WAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 341-346 doi: 10.15302/J-FASE-2015082

Abstract: In addition, the aerogels show a high electromagnetic interference (EMI) value of 19.4 dB.

Keywords： cellulose aerogels     carbon nanotubes     electromagnetic interference shielding     composites    

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Electromagnetic interference modeling and suppression techniques in variable-frequency drive systems

Le YANG, Shuo WANG, Jianghua FENG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 3,   Pages 329-353 doi: 10.1007/s11465-018-0466-1

Abstract:

Electromagnetic interference (EMI) causes electromechanical damage to the motors and degrades the

Keywords： variable-frequency drive (VFD)     electromagnetic interference (EMI)     motor drive modeling     EMI noise suppression    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The effects of hypoxia on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factor-1α (HIF-1α) were investigated. The Hela cells were divided into three groups, namely, H (non-transfected Hela cells), H (pGenesil-1 empty plasmid-transfected Hela cells), and H (HIF-1α-shRNA plasmid-transfected Hela cells), and were cultured under hypoxia (1% O) and normoxia for 48h. The expression of HIF-1α, E-cadherin, β-catenin, and actin was detected using Western blot. The scratch test and the invasion assay were applied to examine the invasion in each group. The expression of HIF-1α, E-cadherin, and β-catenin in tumor grafts was assayed immunohistochemically. Western blot results revealed that the bands of HIF-1α, E-cadherin, β-catenin, and actin proteins were detected in the H and H groups under hypoxia for 48h. The expression of E-cadherin, β-catenin, and actin was detected in the H group under hypoxia for 48h, and normoxia. In the H, H, and H groups under normoxia, and the H group under hypoxia for 48h, no expression of HIF-1α was detectable. The scratch test showed that the invasive ability in the H group was significantly alleviated. Immunohistochemically, it was found that there was a significant difference in the expression of HIF-1α, E-cadherin, and β-catenin between the H and H groups (<0.05), but the difference was not significant between the H and H groups. It was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and the expression of related proteins (E-cadherin, β-catenin, and actin) depend on HIF-1α.

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Experimental study of aerodynamic interference effects on aerostatic coefficients of twin deck bridges

Zhiwen LIU , Zhengqing CHEN , Gao LIU , Xinpeng SHAO ,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 3,   Pages 292-298 doi: 10.1007/s11709-009-0048-8

Abstract: The aerodynamic interference effects on aerostatic coefficients of twin deck bridges with large spanand torque coefficients of windward and leeward decks are also affected slightly by the aerodynamic interferenceAnd the aerodynamic interference effects on lift and torque coefficients of twin decks can be neglected

Keywords： twin decks     aerodynamic interference effects     aerostatic coefficients     wind tunnel test    

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Calculation method of radial stress and deformation on conic threaded connections with interference fit

Shoujun CHEN, Qiang LI, Qi AN,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 302-307 doi: 10.1007/s11465-010-0018-9

Abstract: calculation method for radial stress distribution and deformation on conic threaded connections with interferenceoffers a new way of calculating the radial stress and deformation on conic thread connections with interference

Keywords： conic threaded connections     interference fit     radial stress     deformation     finite element analysis (FEA)    

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Design of packing cup interference fit value of hypercompressors for low density polyethylene production

Da LEI,Xuehong LI,Yun LI,Xiwen REN

Frontiers in Energy 2019, Volume 13, Issue 1,   Pages 107-113 doi: 10.1007/s11708-017-0450-1

Abstract: A packing cup is the basic unit of cylinder packing, assembled by the interference fit between an innerThe traditional method of designing the interference fit value for packing cups depends on the shrink-fitThe traditional method neglects the influence of axial preloading on the interference mating pressureA higher interference fit value accepted by the traditional method may not be feasible as it might alreadyAlong with fatigue analysis, the feasible range of interference fit value has been modified by utilizing

Keywords： interference fit value     packing cup     hypercompressor     finite element method (FEM)    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: Specific Src siRNA was transfected into cultured mouse neuroblastoma N2a cells to inhibit the expressionY307 and tau at different sites, as well as PP2A activity were detected at different time points after siRNATwelve hours after siRNA transfection, the protein level of Src was dramatically decreased, with decreased

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Damage propagation and strength prediction of a single-lap interference-fit laminate structure

Peng ZOU, Xiangming CHEN, Hao CHEN, Guanhua XU

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 4,   Pages 558-570 doi: 10.1007/s11465-020-0591-5

Abstract: Experimental and finite element research was conducted on the bolted interference fit of a single-lap

Keywords： single-lap     interference fit     secondary bending moment     damage mechanism     bearing strength    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: The inhibition of pirh2 expression by siRNA (psiRNA-pirh2) resulted in reduced cell proliferation and

Keywords： control     interruption     cytoplasm     number     growth    

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Title Author Date Type Operation

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Elastoplastic frictional contact problem study on interference fits of compressor

ZHANG Hongwu, WU Changhua, LIAO Aihua

Journal Article

Laser interference fabrication of large-area functional periodic structure surface

Lei WANG, Zi-Han WANG, Yan-Hao YU, Hong-Bo SUN

Journal Article

Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article

with multi-walled carbon nanotubes: preparation, characterization, and application for electromagnetic interference

Jian LI,Caichao WAN

Journal Article

Electromagnetic interference modeling and suppression techniques in variable-frequency drive systems

Le YANG, Shuo WANG, Jianghua FENG

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

Experimental study of aerodynamic interference effects on aerostatic coefficients of twin deck bridges

Zhiwen LIU , Zhengqing CHEN , Gao LIU , Xinpeng SHAO ,

Journal Article

Calculation method of radial stress and deformation on conic threaded connections with interference fit

Shoujun CHEN, Qiang LI, Qi AN,

Journal Article

Design of packing cup interference fit value of hypercompressors for low density polyethylene production

Da LEI,Xuehong LI,Yun LI,Xiwen REN

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Damage propagation and strength prediction of a single-lap interference-fit laminate structure

Peng ZOU, Xiangming CHEN, Hao CHEN, Guanhua XU

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article